Synthetic approach for unsaturated precursors for parahydrogen induced polarization of choline and its analogs

RV Shchepin, EY Chekmenev

Index: Shchepin, Roman V.; Chekmenev, Eduard Y. Journal of Labelled Compounds and Radiopharmaceuticals, 2013 , vol. 56, # 13 p. 655 - 662

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Citation Number: 6

Abstract

Reported here are (i) a new synthetic approach for preparation of (ii) a new compound class, of–OH, for example, an–OH group is replaced with acetyl protecting group, protected 1, 2- dehydrocholine analogs and (iii) a new synthetic route for betaine aldehyde. The C¼C bond of 1, 2-dehydrocholine moiety can be used for molecular addition of parahydrogen producing–OH protected hyperpolarized choline by parahydrogen-induced polarization ( ...