New Method for the Synthesis of Diversely Functionalized Imidazoles from N-Acylated α-Aminonitriles

YL Zhong, J Lee, RA Reamer, D Askin

Index: Organic Letters, , vol. 6, # 6 p. 929 - 931

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Citation Number: 54

Abstract

... Volume: Page: ... Organic Letters. ... 1H-imidazole 2, a key intermediate for the synthesis of Cozaar 1 (Scheme 3). The imidazole precursor 21 was simply prepared in 70% overall yield from the reaction of benzyloxyacetaldehyde and sodium cyanide, 6 followed by ...