Subnanomolar inhibitor of cytochrome bc 1 complex designed by optimizing interaction with conformationally flexible residues

PL Zhao, L Wang, XL Zhu, X Huang…

Index: Bolgunas, Stephen; Clark, David A.; Hanna, Wayne S.; Mauvais, Patricia A.; Pember, Steve O. Journal of Medicinal Chemistry, 2006 , vol. 49, # 15 p. 4762 - 4766

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Citation Number: 76

Abstract

... Journal of the ... Due to its subnanomolar K i potency and slow dissociation rate constant (k −0 = 0.00358 s −1 ), 5c could be used as a specific ... 1 complex, always named Q o I fungicides, have been introduced into the agricultural fungicide market.(13, 14) The first Q o I fungicides ...