Electron Impact Induced Loss of C??5/C??8 Substituents of 1, 2, 3, 4??Tetrahydroisoquinolines, VI1): Synthesis and Mass Spectrometric Fragmentation of Dihydroindole …

…, W Wiegrebe, UP Schlunegger, R Lauber

Index: Knefeli; Mayer; Wiegrebe; Schlunegger; Lauber Archiv der Pharmazie, 1990 , vol. 323, # 3 p. 145 - 155

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Citation Number: 4

Abstract

Abstract The syntheses of the C-4 substituted dihydroindoles 25, 31 (scheme 7), and 36 (scheme 8) are described.-The CID MIKE spectrum in the 2. field free region (2. FFR) of m/z 146 from 25 is very similar to but not identical with that of m/z 146 from the C-5 substituted tetrahydroisoquinolines 3, 6, 7, and 8 (scheme 2), so supporting our hypothesis of a rearrangement in M+ of tetrahydroisoquinolines 1) prior to fragmentation, but not proving it ...