Novel analgesics and molecular rearrangements in the morphine-thebaine group. III. Alcohols of the 6, 14-endo-ethenotetrahydrooripavine series and derived …

KW Bentley, DG Hardy

Index: Bentley,K.W.; Hardy,D.G. Journal of the American Chemical Society, 1967 , vol. 89, p. 3281 - 3292

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Citation Number: 135

Abstract

Abstract: Secondary and tertiary alcohols of general structures IV and V have been prepared by the demethylation of the corresponding bases I and I1 described in part I1 of this series. The phenols so obtained are analgesics of extremely high potency, up to an unprecedented 12,000 times that of morphine. The bases of this and earlier series have been converted into analogs of N-allylnormorphine and N-allylnorcodeine of general structures XI and XI1 via ...