Chemistry and pharmacology of the non-benzodiazepine anxiolytic enciprazine and related compounds

…, I Fleischhauer, V Jakovlev, A Kleemann…

Index: Engel, Juergen; Fleischhauer, Ilona; Jakovlev, Vladimir; Kleemann, Axel; Kutscher, Bernhard; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 11 p. 2976 - 2981

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Citation Number: 6

Abstract

Acknowledgment. One of us (MS) is thankful to the Director, CDRI for the award of a research fellowship. ... Y l7 MR IA log 1/1, IT 1 .00 ... MR d -0.16 1.00 0.48 0.16 1.00 IA -0.32 -0.08 -0.04 1.00 log l/Iso 0.50 0.00 0.51 0.57 1 .00 ... The experimental values for NOz and C1, namely -0.28 and 0.71, obtained by subtracting log P of le from that of IC and log P of 10b from that of lOd, respectively, were found to be in agreement with the corresponding values in the ...

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