Syntheses with organoboranes. XIII. Synthesis of ω-(4-bromophenyl) alkanoic acids and their borylation

M Zaidlewicz, A Wolan

Index: Zaidlewicz, Marek; Wolan, Andrzej Journal of Organometallic Chemistry, 2002 , vol. 657, # 1-2 p. 129 - 135

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Citation Number: 23

Abstract

ω-(4-Bromophenyl) alkanoic acids 2c–e were obtained from 1-bromo-4-alkenylbenzenes 5c– e by hydroboration–thermal isomerization–oxidation. Their esters 11c–e were transformed in good yields into the corresponding boronates 12c–e by the cross-coupling reaction with 4, 4, 5, 5, 4′, 4′, 5′, 5′-octamethyl [2, 2′] bi [[1, 3, 2] dioxaborolanyl](10) in an ionic liquid,[bmim][BF4]. The use of pinacolborane for the coupling reaction in the ionic liquid ...