New synthetic thiocolchicine derivatives as lowtoxic anticancer agents

SH Lee, SK Park, JM Kim, MH Kim, KH Kim…

Index: Lee, Sun-Hee; Park, Sun-Kyoung; Kim, Jeong-Mi; Kim, Myung-Hwa; Kim, Kwang-Hee; Chun, Kwang-Woo; Cho, Kyung-Hea; Youn, Ji-Youn; Namgoong, Sung Keon Archiv der Pharmazie, 2005 , vol. 338, # 12 p. 582 - 589

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Citation Number: 9

Abstract

Abstract New thiocolchicine derivatives (1–8) were designed as less toxic anticancer agents possessing the power ful anticancer activity of colchicine. The synthesis and biological evaluation of these compounds were described. As a preliminary result of biological in vitro investigation, compounds 1, 6, and 7 showed lower toxicities than that of colchicine in combination with potent anticancer activities.