Design and synthesis of a biologically active antibody mimic based on an antibody-antigen crystal structure

ML Smythe, M Von Itzstein

Index: Smythe; Von Itzstein Journal of the American Chemical Society, 1994 , vol. 116, # 7 p. 2725 - 2733

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Citation Number: 41

Abstract

Abstract: We have used the crystal structure of an N9 sialidase (antigen)-NC41 (antibody) complex to design a low molecular weight compound that mimics the binding function of the macromolecular antibody. The components of recognition between the antibody and the protein antigen have been analyzed from the energy-refined crystal complex. From this analysis, four amino acid residues on the antibody binding surface, which make direct ...