3-Alkyl-(5, 5′-diphenyl) imidazolidinediones as new cannabinoid receptor ligands

M Kanyonyo, SJ Govaerts, E Hermans…

Index: Kanyonyo, Martial; Govaerts, Sophie J.; Hermans, Emmanuel; Poupaert, Jacques H.; Lambert, Didier M. Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 15 p. 2233 - 2236

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Citation Number: 46

Abstract

Twenty-four 3-alkyl-(5, 5′-diphenyl) imidazolidinediones were synthesized and evaluated as new cannabinoid receptor ligands. Three compounds exhibited a Ki value around 100 nM against [3H]-SR 141716A binding obtained from human CB1 transfected CHO cells membranes. The lack of change of affinity in the presence of a non hydrolyzable GTP analogue seems to indicate they are cannabinoid antagonists.