Tetrahedron Letters

Examination of the olefin–olefin ring closing metathesis to prepare Latrunculin B

J She, JW Lampe, AB Polianski, PS Watson

Index: She, Jin; Lampe, John W.; Polianski, Alexandra B.; Watson, Paul S. Tetrahedron Letters, 2009 , vol. 50, # 3 p. 298 - 301

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Citation Number: 9

Abstract

Three subunits of the potent actin polymerization inhibitor Latrunculin B were synthesized and assembled using olefin–olefin ring closing metathesis chemistry to close the 14- membered macrocycle. Metathesis reactions of substrates with various remote protecting group patterns were examined and gave 6, 7-E-lactones as the preferred products.