Tetrahedron: Asymmetry

An efficient synthesis of (R)-3-hydroxytetradecanoic acid

G Huang, RI Hollingsworth

Index: Huang, Guangfei; Hollingsworth, Rawle I. Tetrahedron Asymmetry, 1998 , vol. 9, # 23 p. 4113 - 4115

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Citation Number: 16

Abstract

Although several methods have been reported for the formation of 3-hydroxy acids,[3]current syntheses for (R)-3-hydroxytetradecanoic acid either give products in low optical purity, [4]in low yield[5]or are limited to small scale preparations.[6]3-Hydroxytetradecanoic acid of very high optical purity is essential for the synthesis of lipid A because at least four such fatty acid residues are present. A synthesis employing a fatty acid preparation that was 93% optically pure ...

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