Tetrahedron letters

Traceless solid-phase synthesis of 2-amino-5-alkylidene-thiazol-4-ones

M Pulici, F Quartieri

Index: Pulici, Maurizio; Quartieri, Francesca Tetrahedron Letters, 2005 , vol. 46, # 14 p. 2387 - 2391

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Citation Number: 40

Abstract

2-Amino-5-alkylidene-thiazol-4-ones bearing two diversity points are prepared by a solid- phase strategy exploiting rhodanine as the starting material. Rhodanine is first loaded on bromo-Wang resin, subjected to Knovenagel condensation with aldehydes, and cleaved off the resin in a traceless manner by means of an amine.