Tetrahedron letters

Metal oxide in aqueous organic solution promoted chemoselective N-sulfonylation of hydrophilic amino alcohols

HH Kang, HS Rho, DH Kim, SG Oh

Index: Kang, Hak Hee; Rho, Ho Sik; Kim, Duck Hee; Oh, Seong-Geun Tetrahedron Letters, 2003 , vol. 44, # 38 p. 7225 - 7227

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Citation Number: 10

Abstract

The reaction of hydrophilic amino alcohols with sulfonyl chlorides in the presence of metal oxide (MgO, CuO, Ag2O) in aqueous organic solution cleanly provided alkanolsulfonamide. Advantages of this method were mild, neutral reaction conditions, chemoselectivity and easy