Bioorganic & medicinal chemistry

Microbial transformation of 2-hydroxy and 2-acetoxy ketones with Geotrichum sp.

ZL Wei, GQ Lin, ZY Li

Index: Wei, Zhi-Liang; Lin, Guo-Qiang; Li, Zu-Yi Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 5 p. 1129 - 1137

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Citation Number: 44

Abstract

Biotransformation of a series of o-, m-and p-substituted α-hydroxy-and α- acetoxyphenylethanones 1a–h and 9a–g with Geotrichum sp. led to the corresponding 1, 2- diols 2 and/or monoacetates 10 in moderate to excellent enantiomeric excesses. α-Hydroxy-