Synthesis, Anti??tubulin and Antiproliferative SAR of Steroidomimetic Dihydroisoquinolinones

…, W Dohle, MP Thomas, E Hamel, E Ferrandis…

Index: Leese, Mathew P.; Jourdan, Fabrice L.; Major, Meriel R.; Dohle, Wolfgang; Thomas, Mark P.; Hamel, Ernest; Ferrandis, Eric; Mahon, Mary F.; Newman, Simon P.; Purohit, Atul; Potter, Barry V. L. ChemMedChem, 2014 , vol. 9, # 4 p. 798 - 812

Full Text: HTML

Citation Number: 4

Abstract

Abstract A SAR translation strategy adopted for the discovery of tetrahydroisoquinolinone (THIQ)-based steroidomimetic microtubule disruptors has been extended to dihydroisoquinolinone (DHIQ)-based compounds. A steroid A, B-ring-mimicking DHIQ core was connected to methoxyaryl D-ring mimics through methylene, carbonyl, and sulfonyl linkers, and the resulting compounds were evaluated against two cancer cell lines. The ...

Related Articles:

Monomethyl ether derivatives of 7, 8-dihydroxy-and 8, 9-dihydroxy-4-propyl-1, 2, 3, 4, 4a, 5, 6, 10b-octahydrobenzo [f] quinolines as possible products of metabolism …

[Cannon, Joseph G.; Walker, Kathleen A.; Montanari, Antonio; Long, John Paul; Flynn, Jan R. Journal of Medicinal Chemistry, 1990 , vol. 33, # 7 p. 2000 - 2006]

Monomethyl ether derivatives of 7, 8-dihydroxy-and 8, 9-dihydroxy-4-propyl-1, 2, 3, 4, 4a, 5, 6, 10b-octahydrobenzo [f] quinolines as possible products of metabolism …

[Journal of Medicinal Chemistry, , vol. 33, # 7 p. 2000 - 2006]

Synthesis and biological evaluation of 4′-(6, 7-disubstituted-2, 4-dihydro-indeno [1, 2-c] pyrazol-3-yl)-biphenyl-4-ol as potent Chk1 inhibitors

[Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 15 p. 4308 - 4315]

More Articles...