Development of Designed Site-Directed Pseudopeptide-Peptido-Mimetic Immunogens as Novel Minimal Subunit-Vaccine Candidates for Malaria

…, LP Lesmes, LF Carreño, GM Gallego, ME Patarroyo

Index: Lozano, Jose Manuel; Lesmes, Liliana P.; Carreno, Luisa F.; Gallego, Gina M.; Patarroyo, Manuel Elkin Molecules, 2010 , vol. 15, # 12 p. 8856 - 8889

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Citation Number: 7

Abstract

Abstract Synthetic vaccines constitute the most promising tools for controlling and preventing infectious diseases. When synthetic immunogens are designed from the pathogen native sequences, these are normally poorly immunogenic and do not induce protection, as demonstrated in our research. After attempting many synthetic strategies for improving the immunogenicity properties of these sequences, the approach consisting of identifying high ...