The efficient preparation of di-and tripeptides by coupling N-(Cbz-or Fmoc-α-aminoacyl) benzotriazoles with unprotected amino acids
AR Katritzky, P Angrish, K Suzuki
Index: Katritzky, Alan R.; Angrish, Parul; Suzuki, Kazuyuki Synthesis, 2006 , # 3 p. 411 - 424
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Citation Number: 43
Abstract
Abstract N-(Cbz-or Fmoc-α-aminoacyl) benzotriazoles 2 and N-protected peptidoylbenzotriazoles 6 are coupled in aqueous acetonitrile solution with free amino acids or dipeptides to prepare:(i) 22 chirally pure dipeptides 5a-v (in an average yield of 82%) from N-(Cbz-or Fmoc-α-aminoacyl) benzotriazoles 2 and unprotected amino acids,(ii) five chiral tripeptides 7a-e (in an average yield of 75%) from N-protected ...
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