Design, synthesis and preliminary evaluation of α-sulfonyl γ-(glycinyl-amino) proline peptidomimetics as matrix metalloproteinase inhibitors

J Zhang, X Li, Y Jiang, J Feng, X Li, Y Zhang…

Index: Zhang, Jian; Li, Xiaoyang; Jiang, Yuqi; Feng, Jinhong; Li, Xiaoguang; Zhang, Yingjie; Xu, Wenfang Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 11 p. 3055 - 3064

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Abstract

Abstract A series of novel α-sulfonyl γ-(glycinyl-amino) proline peptidomimetic derivatives were designed, synthesized and assayed for their activities against matrix metalloproteinase- 2 (MMP-2), aminopeptidase N (APN)/CD13 and HDACs. The results indicated that all the compounds exhibited highly selective inhibition against MMP-2 as compared with APN and HDACs. The antiproliferative activities of some compounds against SKOV3, HL60 and ...

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