Synthesis and binding affinities of analogs of cholecystokinin-(30-33) as probes for central nervous system cholecystokinin receptors

DC Horwell, A Beeby, CR Clark…

Index: Horwell; Beeby; Clark; Hughes Journal of Medicinal Chemistry, 1987 , vol. 30, # 4 p. 729 - 732

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Citation Number: 38

Abstract

CCK-30-33 has been identified as the minimum fragment of CCK with nanomolar affinity for the central CCK receptors, as assayed by displacement of [3H]-Boc-p-alanyl-CCK-30-33 (pentagastrin) in homogenized mouse cerebral cortex. Examination of binding using this assay in the two series Boc-Trp-X-Phe-NH2 when X= Met-Asp (Boc-CCK-30-33), Gly-Asp, Met-Gly, and Gly-Gly and when X=(CH,),(n= 0-4) reveals that modification of the ...