Archiv der Pharmazie

Synthesis and Aldose Reductase Inhibitory Activities of Novel O??Substituted Hydroxyphenylacetic Acid Derivatives

D Rakowitz, H Angerer, B Matuszczak

Index: Rakowitz, Dietmar; Angerer, Helga; Matuszczak, Barbara Archiv der Pharmazie, 2006 , vol. 339, # 10 p. 547 - 558

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Citation Number: 3

Abstract

Abstract In continuation of our work aimed towards the preparation of novel aldose reductase inhibitors, several O-substituted hydroxyphenylacetic acid derivatives were investigated. The highest inhibitory activity was found for compounds 7b and 7c bearing a cyclohexylmethyl substituent. This result demonstrates that within these series, this moiety is a useful surrogate for the 4-bromo-2-fluorobenzyl residue which can be often found in ...