Tetrahedron

Synthesis of substituted [1, 3] thiazolo [4, 5-b] pyridines and [1, 3] thiazolo [4, 5-d][1, 2, 3] triazines

D Thomae, E Perspicace, S Hesse, G Kirsch, P Seck

Index: Thomae, David; Perspicace, Enrico; Hesse, Stephanie; Kirsch, Gilbert; Seck, Pierre Tetrahedron, 2008 , vol. 64, # 39 p. 9309 - 9314

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Citation Number: 40

Abstract

In this work, we described an easy preparation of substituted 4-amino-5-cyano-1, 3- thiazoles. These compounds have been used as starting materials to obtain two classes of compounds. New substituted [1, 3] thiazolo [4, 5-e] pyridines were synthesized in one step via Friedländer reaction. Diazotation of 4-amino-5-cyano-1, 3-thiazoles afforded 4-chloro [1, 3] thiazolo [4, 5-d][1, 2, 3] triazines in one step. The later was substituted by a secondary ...

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