Canadian Journal of Chemistry

Microwave-assisted, palladium-catalyzed carbonylative cyclization-Rapid synthesis of 2-quinolones from unprotected 2-iodoanilines and terminal alkynes

JR Chen, J Liao, WJ Xiao

Index: Chen, Jia-Rong; Liao, Jie; Xiao, Wen-Jing Canadian Journal of Chemistry, 2010 , vol. 88, # 4 p. 331 - 337

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Citation Number: 12

Abstract

Palladium-catalyzed cyclocarbonylations of 2-iodoanilines with various terminal alkynes have been carried out by the use of commercially available molybdenum hexacarbonyl as a convenient and solid carbon monoxide source. The reactions were conducted at 160° C for 30 min under microwave irradiation and in the presence of Et3N in THF, affording the corresponding 2-quinolone derivatives in good regioselectivities and yields.