Tetrahedron letters

Regiospecific alkylation of β-ketothioesters and use in the synthesis of acyl-tetronic acids

PM Booth, CMJ Fox, SV Ley

Index: Booth, Paul M.; Fox, Christina M. J.; Ley, Steven V. Tetrahedron Letters, 1983 , vol. 24, # 46 p. 5143 - 5146

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Citation Number: 21

Abstract

Abstract Anions of t-butylacetothioacetate (1) react with alkylhalides and carbonyl compounds in a regiospecific manner to afford products which are versatile synthetic intermediates as exemplified by short syntheses of the mold metabolites carolic acid (2) and carlosic acid (3).

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