A Direct Copper-Promoted Three-Component Entry to Trifluoromethylketoximes

S Wang, J Nie, Y Zheng, JA Ma

Index: Wang, Shuai; Nie, Jing; Zheng, Yan; Ma, Jun-An Organic Letters, 2014 , vol. 16, # 6 p. 1606 - 1609

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Citation Number: 20

Abstract

A new copper-promoted three-component method for constructing ketoximes has been developed. This transformation can be achieved using indoles/pyrroles with the in situ generated 2, 2, 2-trifluorodiazoethane and nitrite species under mild conditions, thus offering a direct pathway to (E)-3-indolyl/2-pyrrolyl trifluoromethylketoximes.