Catalytic asymmetric synthesis of R207910

…, R Motoki, S Makino, Y Shimizu, M Kanai…

Index: Saga, Yutaka; Motoki, Rie; Makino, Sae; Shimizu, Yohei; Kanai, Motomu; Shibasaki, Masakatsu Journal of the American Chemical Society, 2010 , vol. 132, # 23 p. 7905 - 7907

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Citation Number: 27

Abstract

The first asymmetric synthesis of a very promising antituberculosis drug candidate, R207910, was achieved by developing two novel catalytic transformations; a catalytic enantioselective proton migration and a catalytic diastereoselective allylation of an intermediate α-chiral ketone. Using 2.5 mol% of a Y-catalyst derived from Y (HMDS) 3 and the new chiral ligand 9, 1.25 mol% of p-methoxypyridine N-oxide (MEPO), and 0.5 mol% ...