4-Phenyl tetrahydroisoquinolines as dual norepinephrine and dopamine reuptake inhibitors

AD Pechulis, JP Beck, MA Curry, MA Wolf…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 23 p. 7219 - 7222

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Citation Number: 6

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... our medicinal chemistry efforts explored novel tetrahydroisoquinolines (THIQs) lacking the aniline moiety of 1 with high NET potency (K i <15 nM), 2- to 10-fold selectivity over DAT and >25-fold selectivity for NET over SERT. ...

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