Analogues with fluorescent leaving groups for screening and selection of enzymes that efficiently hydrolyze organophosphorus nerve agents

L Briseno-Roa, J Hill, S Notman, D Sellers…

Index: Journal of Medicinal Chemistry, , vol. 49, # 1 p. 246 - 255

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Citation Number: 68

Abstract

... Journal of Medicinal Chemistry. ... b The 'catalytic efficiencies' of BuChE are k cat /K d values. c ND = not determined. It could also be attractive to use enzymes which hydrolyze NAs for medical treatment of individuals exposed, or at risk of exposure, to CW agents. ...