Pharmaceutical research

Synthesis and β-adrenergic activities of R-fluoronaphthyloxypropanolamine

A Adejare, SS Sciberras

Index: Adejare, Adeboye; Sciberras, Sophie S. Pharmaceutical Research, 1997 , vol. 14, # 4 p. 533 - 536

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Citation Number: 8

Abstract

Abstract Purpose. Many biogenic amines where an aromatic proton is substituted with fluorine have exhibited pharmacological properties that are dependent on the position of fluorine on the aromatic ring. For example, 6-fluoroepinephrine is selective for α-adrenergic receptors whereas the 2-fluoroisomer is selective for β-receptors. Aryloxypropanolamines are β-receptor agonists or antagonists, depending on the aryl group and its substituents. ...

A Convenient Large-Scale Synthesis of 4-Fluoro-1-naphthaldehyde and Its Aromatic Nucleophilic Substitution Reactions

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Fluorination with cesium fluoroxysulfate. Room temperature fluorination of benzene and naphthalene derivatives

[Journal of Organic Chemistry, , vol. 50, # 19 p. 3609 - 3612]

Synthesis and biological activity of some known and putative duloxetine metabolites

[Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 13 p. 3481 - 3486]