Tetrahedron

Metalated fluoropyridines and fluoroquinolines as reactive intermediates: new ways for their regioselective generation

G Shi, S Takagishi, M Schlosser

Index: Shi, Guo-qiang; Takagishi, Sadahito; Schlosser, Manfred Tetrahedron, 1994 , vol. 50, # 4 p. 1129 - 1134

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Citation Number: 38

Abstract

The mixture of lithium diisopropylamide and potassium tert-butoxide (“LIDA-KOR reagent”) is a powerful base which can be advantageously employed for the regioselective deprotonation of fluoropyridines and, in particular, 3-fluoroquinoline. A novel cyclization process was elaborated for the preparation of the latter product.