Organic letters

Palladium-catalyzed direct alkynylation of C− H bonds in benzenes

M Tobisu, Y Ano, N Chatani

Index: Tobisu, Mamoru; Ano, Yusuke; Chatani, Naoto Organic Letters, 2009 , vol. 11, # 15 p. 3250 - 3252

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Citation Number: 127

Abstract

Alkynylarenes constitute an important class of substructures due to their utility as synthetic intermediates and as versatile structural motifs in supramolecular and materials chemistry. The most frequently utilized method for the preparation of alkynylarenes is the Sonogashira−Hagihara reaction, in which C(aryl)−C(sp) bonds are constructed by the palladium/copper-catalyzed cross-coupling of aryl halides and terminal alkynes (Scheme 1a).(1) On the other hand, catalytic aromatic ...

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