Synthesis of a biphenyl library for studies of hydrogen bonding in the solid state

…, MD Antonijevic, GJ Tizzard, SJ Coles, J Spencer

Index: Baltus, Christine B.; Press, Neil J.; Antonijevic, Milan D.; Tizzard, Graham J.; Coles, Simon J.; Spencer, John Tetrahedron, 2012 , vol. 68, # 45 p. 9272 - 9277

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Citation Number: 6

Abstract

A biphenyl library incorporating amide and sulfonamide groups has been synthesised via microwave-mediated Suzuki–Miyaura couplings. Many derivatives were crystallised from dichloromethane/methanol and analysed by single crystal X-ray diffraction. An interesting structure was obtained for N-(4′-methylbiphenyl-4-yl) acetamide with Z′= 6 and hydrogen- bonding networks of the type N–H… O in the unit cell.