Chiral ferrocenyl amino alcohols for enantioselective additions of diethylzinc to aldehydes

…, M Ginj, J Brocard, L Pélinski, G Novogrocki

Index: Bastin, Stephanie; Ginj, Mihaela; Brocard, Jacques; Pelinski, Lydie; Novogrocki, Guy Tetrahedron Asymmetry, 2003 , vol. 14, # 12 p. 1701 - 1708

Full Text: HTML

Citation Number: 26

Abstract

Optically active ferrocenyl amino alcohols have been prepared from commercially available l- alaninol, l-leucinol and l-valinol. They have been utilized as chiral ligands in the catalytic addition of diethylzinc to aldehydes. The influence of the substituents on the stereogenic centers of the ligand has been studied. Enantioselectivities up to 95% have been obtained.

Related Articles:

Diastereoselective synthesis and bioactivity of long-chain anti-2-amino-3-alkanols

[Chen, Bi-Shuang; Yang, Long-He; Ye, Jian-Liang; Huang, Tao; Ruan, Yuan-Ping; Fu, Jin; Huang, Pei-Qiang European Journal of Medicinal Chemistry, 2011 , vol. 46, # 11 p. 5480 - 5486]

Stereoselective Synthesis of the Four Stereoisomers of 4-(N, N-Dibenzylamino)-2, 2-dimethyl-3-hydroxypentanenitrile

[Synthetic Communications, , vol. 27, # 18 p. 3227 - 3234]

The power of visual imagery in drug design. Isopavines as a new class of morphinomimetics and their human opioid receptor binding activity

[Journal of Medicinal Chemistry, , vol. 46, # 1 p. 34 - 48]

Diastereoselective synthesis and bioactivity of long-chain anti-2-amino-3-alkanols

[European Journal of Medicinal Chemistry, , vol. 46, # 11 p. 5480 - 5486]

More Articles...