Total syntheses of new proansamitocin derivatives by ring-closing metathesis

A Meyer, A Kirschning

Index: Meyer, Axel; Kirschning, Andreas Synlett, 2007 , # 8 p. 1264 - 1268

Full Text: HTML

Citation Number: 4

Abstract

Recently, we initiated a research program [11] [12] dedicated to access new ansamitocins by synthetically exploiting the 3-amino-5-hydroxybenzoic acid (AHBA) block mutant of the ansamitocin P-3 producer Actinosynnema pretiosum (HGF073). [13] As part of this project we had to prepare proansamitocin (4), the polyketide ring-closure product, and analogues 5 and 6 which are basically 17-membered macrocycles missing the first propionate unit of the ketide chain (marked in ...