Tetrakis (dimethylamino) ethylene (TDAE) as a useful reductant of some chlorodifluoromethylated ketones. A new approach for the synthesis of α, α-difluoroketone …

C Burkholder, WR Dolbier, M Me, A Ndedi

Index: Burkholder, Conrad; Dolbier Jr., William R.; Medebielle, Maurice; Ndedi, Alexandre Tetrahedron Letters, 1998 , vol. 39, # 48 p. 8853 - 8856

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Citation Number: 26

Abstract

Tetrakis (dimethylamino) ethylene (TDAE) was found to be an effective reductant of chlorodifluoromethylated ketones1–3. The generated α, α-difluoroacetyl anion was trapped with several aldehydes4–7, under mild conditions, to give the corresponding 2, 2-difluoro-3- hydroxy ketone derivatives8–13, in moderate yields.