Synthesis and electron-transfer reactions of some 3-difluoroacetylated imidazo [1, 2-a] pyridine derivatives

…, WR Dolbier, M Médebielle, S Ait-Mohand

Index: Burkholder, Conrad; Dolbier Jr., William R.; Medebielle, Maurice; Ait-Mohand, Samia Tetrahedron Letters, 2001 , vol. 42, # 17 p. 3077 - 3080

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Citation Number: 23

Abstract

The synthesis of new 3-chlorodifluoroacetylated imidazo [1, 2-a] pyridines 1–6 and their difluoroacetyl derivatives is presented. The reductive cleavage of the halogenated ketones was investigated by cyclic voltammetry, and tetrakis (dimethylamino) ethylene (TDAE) was found to be an effective reductant for the generation of the corresponding α, α-difluoroacetyl anions and for the synthesis of new gem-difluoromethylated imidazo [1, 2-a] pyridine ...