The Journal of organic chemistry

Synthetic approaches to amino analogues of N-acetylcolchinol

V Colombel, O Baudoin

Index: Colombel, Virginie; Baudoin, Olivier Journal of Organic Chemistry, 2009 , vol. 74, # 11 p. 4329 - 4335

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Citation Number: 8

Abstract

A straightforward synthesis of aminodibenzoxepines, new analogues of N-acetylcolchinol, is reported by using two different strategies. The first strategy involves a Grignard addition, a biaryl Suzuki− Miyaura coupling, and a HF-mediated cyclodehydration as key steps. A second strategy, better adapted to the synthesis of analogues bearing a benzylic substituent, was designed by inverting the order of the Grignard addition and the biaryl coupling. This ...