3-[3-(Piperidin-1-yl) propyl] indoles as highly selective h5-HT1D receptor agonists

…, MB van Niel, B Sohal, AP Watt, L Hitzel…

Index: Russell, Michael G. N.; Matassa, Victor G.; Pengilley, Roy R.; Van Niel, Monique B.; Sohal, Bindi; Watt, Alan P.; Hitzel, Laure; Beer, Margaret S.; Stanton, Josephine A.; Broughton, Howard B.; Castro, Jose L. Journal of Medicinal Chemistry, 1999 , vol. 42, # 24 p. 4981 - 5001

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Citation Number: 24

Abstract

Several 5-HT1D/1B receptor agonists are now entering the marketplace as treatments for migraine. This paper describes the development of selective h5-HT1D receptor agonists as potential antimigraine agents which may produce fewer side effects. A series of 3-[3- (piperidin-1-yl) propyl] indoles has been synthesized which has led to the identification of 80 (L-772,405), a high-affinity h5-HT1D receptor full agonist having 170-fold selectivity for h5- ...