Synthetic Communications®

Asymmetric addition of diethylzinc to ketones promoted by tartaric acid derivatives

A Hui, J Zhang, Z Wang

Index: Hui, Ailing; Zhang, Jintang; Wang, Zhiyong Synthetic Communications, 2008 , vol. 38, # 14 p. 2374 - 2384

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Citation Number: 9

Abstract

Abstract The preparation of new sulfonamide ligands derived from L-tartaric acid and camphor sulfonyl chloride are described. The employment in the titanium tetraisopropoxide- promoted enantioselective addition of diethylzinc to ketones has been studied. The best enantiomeric excess is up to 99% with 7 mol% catalyst loading at room temperature.

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