A method for iodination of oxazoles at C-4 via 2-lithiooxazoles

E Vedejs, LM Luchetta

Index: Vedejs, Edwin; Luchetta, Leza M. Journal of Organic Chemistry, 1999 , vol. 64, # 3 p. 1011 - 1014

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Citation Number: 61

Abstract

In connection with a synthesis project, we were interested in testing the palladium-mediated coupling reaction of a 2-unsubstituted 4-halooxazole. However, no prior example of this specific structural type could be found in the literature. Electrophilic halogen sources do react with oxazoles at C-4, but this option is limited by functional group compatibility issues and by competing attack at C-2 and C-5. 1 An alternative approach was sought that would ...