Selective reduction of α??keto esters with organotin hydrides application to asymmetric syntheses

A Rahm, M Pereyre

Index: Rahm, A.; Pereyre, M. Bulletin des Societes Chimiques Belges, 1980 , vol. 89, # 10 p. 843 - 848

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Citation Number: 3

Abstract

Abstract Vrganotin hydrides selectively reduce the keto function group in α-keto esters such as pyruvates or benzoylformates. Hydrostannation of (-) menthyl benzoylformate with achiral reagents occurs with 5–20% asymmetric induction while the reaction of (−) 2 butyl- diphenyltin hydride with ethyl benzoylformate only proceeds with a very low optical yield.