Journal of the American Chemical Society

Direct replacement of oxygen in hydantoins and barbiturates by sulfur

HR Henze, PE Smith

Index: Henze; Smith Journal of the American Chemical Society, 1943 , vol. 65, p. 1090

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Citation Number: 24

Abstract

Although Aleye? claimed to have synthesized a phenyl derivative of 2-thiohydantoinJ it was later demonstrated that the compound is a phenylpseudothiohydantoiri7 (IV). The first preparation of the true 2-thiohydantoin (11) was that of Kla~ on,~ who obtained it by heating the hydrochloride of ethyl aminoacetate with potassium thiocyanate at 140-150. In 1911, Komats~,'~ Wheeler, Nicolet and Johnson, b and Johnson and Sicoletsh reported new ...