The Preparation and Analgesic Activity of Certain Cyanolactams. I

HJ Glenn, M Freifelder, G Stone, E Hertz…

Index: Glenn et al. Journal of the American Chemical Society, 1955 , vol. 77, p. 3080

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Abstract

The reported synthesis4 of y-cyano-y-valerolactam (I) from ethyl levulinate, hydrogen cyanide and ammonia is not particularly attractive.-4 study of this synthesis led to much improved yields, particularly when butyl levulinate was used as the starting ester. The improved preparation is reported in this paper.