Substituted phenyl 4-(2-oxoimidazolidin-1-yl) benzenesulfonamides as antimitotics. Antiproliferative, antiangiogenic and antitumoral activity, and quantitative structure …

S Fortin, L Wei, E Moreau, J Lacroix, MF Côté…

Index: Fortin, Sebastien; Wei, Lianhu; Moreau, Emmanuel; Lacroix, Jacques; Cote, Marie-France; Petitclerc, Eric; Kotra, Lakshmi P.; Gaudreault, Rene C. European Journal of Medicinal Chemistry, 2011 , vol. 46, # 11 p. 5327 - 5342

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Citation Number: 11

Abstract

The importance of the bridge linking the two phenyl moieties of substituted phenyl 4-(2- oxoimidazolidin-1-yl) benzenesulfonates (PIB-SOs) was assessed using a sulfonamide group, which is a bioisostere of sulfonate and ethenyl groups. Forty one phenyl 4-(2- oxoimidazolidin-1-yl) benzenesulfonamide (PIB-SA) derivatives were prepared and biologically evaluated. PIB-SAs exhibit antiproliferative activities at the nanomolar level ...