Synthesis of O-Aryl-diarylphosphinates and Study of Their Interaction with Neurotoxic Esterase and Acetylcholinesterase

GF Makhaeva, SB Fomicheva, LV Zhuravleva…

Index: Makhaeva; Fomicheva; Zhuravleva; Yarkevich; Kharitonov; Malygin Pharmaceutical Chemistry Journal, 2001 , vol. 35, # 4 p. 190 - 192

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Citation Number: 7

Abstract

Many organophosphorus compounds (OPCs), including those used as drugs for the treatment of Alzheimer's disease and glaucoma [1, 2], exhibit significant acute toxicity related to the inhibition of acetylcholinesterase (ACE) activity in neuronal synapses and, in addition, lead to delayed distal neuropathy manifested by a long axon degeneracy in the spinal cord and peripheral nerves. The latter phenomenon is referred to as the delayed neurotoxicity ...

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