An environmentally benign solvent/catalyst-free one-pot synthesis of N-substituted phthalimides via Aza-wittig reaction

M Sathishkumar, K Palanikumar, A Mariappan…

Index: Sathishkumar, Murugan; Palanikumar, Kulandaivel; Mariappan, Arumugam; Archana, Sivasubramaniyan; Ponnuswamy, Alagusundaram Journal of the Iranian Chemical Society, 2012 , vol. 9, # 5 p. 681 - 685

Full Text: HTML

Citation Number: 6

Abstract

Abstract For the first time an environmentally benign solvent/catalyst-free protocol for the synthesis of a variety of N-substituted phthalimides is submitted. It involves a one-pot coupling of nascent phosphazene generated in situ with phthalic anhydride. The protocol is novel in (1) avoiding toxic solvents,(2) no catalyst is employed and (3) no isophthalimide is formed as noted in the prevailing solution phase/catalysed methodology.

Related Articles:

One-Pot Esterification and Amide Formation via Acid-Catalyzed Dehydration and Ritter Reactions

[Dawar, Pankaj; Raju, M. Bagavan; Ramakrishna, Ramesha Andagar Synthetic Communications, 2014 , vol. 44, # 6 p. 836 - 846]

Synthesis of tetrahydrophthalazine and phthalamide (phthalimide) derivatives via palladium-catalysed carbonylation of iodoarenes

[Tetrahedron, , vol. 67, # 47 p. 9122 - 9128]

One-pot esterification and Ritter reaction: chemo-and regioselectivity from tert-butyl methyl ether

[Dawar, Pankaj; Bhagavan Raju; Ramakrishna, Ramesha A. Tetrahedron Letters, 2011 , vol. 52, # 33 p. 4262 - 4265]

Scope of phthalimido chemistry I. Extension of utility by conversion to the opcb protecting group.

[Astleford, Bret; Weigel, Leland O. Tetrahedron Letters, 1991 , vol. 32, # 28 p. 3301 - 3304]

Chemoselective Esterification and Amidation of Carboxylic Acids with Imidazole Carbamates and Ureas

[Heller, Stephen T.; Sarpong, Richmond Organic Letters, 2010 , vol. 12, # 20 p. 4572 - 4575]

More Articles...