Synthesis, characterization, and anticancer activity of a series of ketone-N4-substituted thiosemicarbazones and their ruthenium (II) arene complexes

…, P Li, X Lei, Q Xiao, S Huang, C Huang, J Cui

Index: Su, Wei; Qian, Quanquan; Li, Peiyuan; Lei, Xiaolin; Xiao, Qi; Huang, Shan; Huang, Chusheng; Cui, Jianguo Inorganic Chemistry, 2013 , vol. 52, # 21 p. 12440 - 12449

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Citation Number: 24

Abstract

Although the TSC Ru-arene complexes have been proven to have potential as effective anticancer drugs, their distinct modes of action and biological targets are still the focus of active research. In this Article, a series of TSC derivatives (L1–L9) and their corresponding Ru(II)-arene complexes (1–9) were synthesized and characterized. The cytotoxicity toward the SGC-7901 human gastric and BEL-7404 human liver cancer cell lines of these compounds was ...