Preparation of N-Substituted 1-(3', 4'-Dihydroxyphenyl)-2-aminoethanols

JR Corrigan, MJ Langermann…

Index: Corrigan; Langermann; Moore Journal of the American Chemical Society, 1949 , vol. 71, p. 530

Full Text: HTML

Citation Number: 10

Abstract

Our investigations were prompted by an observation of Konzett4 that l-(@-hydroxyphenyl)-2- isopropylaminoethanol was more active as a broncholdilator than the N-methyl analog (Synephrine). Konzett4 also studied the broncholytic properties of several N-alkyl analogs of epinephrine and reported that 1-(3 ', 4 '-dihydroxyphenyl}-were isolated in crystalline form. In certain cases where the hydrochlorides resisted crystallization it was found necessary to ...