Design, Synthesis, Structural Characterization by IR, 1H, 13C, 15N, 2D??NMR, X??Ray Diffraction and Evaluation of a New Class of Phenylaminoacetic Acid …

…, AG Bwalya, D Tasdemir, RA Joshi…

Index: Samal, Ramanuj P.; Khedkar, Vijay M.; Pissurlenkar, Raghuvir R. S.; Bwalya, Angela Gono; Tasdemir, Deniz; Joshi, Ramesh A.; Rajamohanan; Puranik, Vedavati G.; Coutinho, Evans C. Chemical Biology and Drug Design, 2013 , vol. 81, # 6 p. 715 - 729

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Citation Number: 9

Abstract

Recent studies have revealed that plasmodial enoyl-ACP reductase (pfENR, FabI), one of the crucial enzymes in the plasmodial type II fatty acid synthesis II (FAS II) pathway, is a promising target for liver stage malaria infections. Hence, pfENR inhibitors have the potential to be used as causal malarial prophylactic agents. In this study, we report the design, synthesis, structural characterization and evaluation of a new class of pfENR inhibitors. The search for ...