Design, Synthesis and Biological Evaluation of Hybrid Molecules Containing Conjugated Styryl Ketone and α-Bromoacryloyl Moieties

…, O Cruz-Lopez, M Kimatrai Salvador…

Index: Romagnoli, Romeo; Baraldi, Pier Giovanni; Cruz-Lopez, Olga; Salvador, Maria Kimatrai; Preti, Delia; Tabrizi, Mojgan Aghazadeh; Balzarini, Jan; Canella, Alessandro; Fabbri, Enrica; Gambari, Roberto Letters in Drug Design and Discovery, 2012 , vol. 9, # 2 p. 140 - 152

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Abstract

There was a major interest in the last years in the design of anticancer agents containing the 1, 5-diaryl-3-oxo-1, 4-pentadienyl system. The modification of this pharmacophore by the introduction of an additional Michael acceptor represents a strategy to obtain novel potential antiproliferative agents. In a continuing study of hybrid compounds containing the α- bromoacryloyl moiety as potential anticancer drugs, we synthesized two novel series of ...